Thursday, February 16, 2012

Find a protein using PDB explorer–describe your protein, including what disease state or other real-world application it has.

         The protein data bank appears to be a website where all the proteins and their functions are located.  This is very useful for record keeping.  The protein that I chose to look at, Kinesin-5 (K5), is found in bipolar disorder.  The protein is 451 amino acids long.  The protein has several β pleated sheets  linkers, and multiple α helix's.  There are approximately 5 subunits.  This protein is a target for small molecule inhibitors which is being used in cancer clinical trials. 
         In conclusion, I think this website was interesting.  It was fun to look at different proteins to see that they look similar yet have a minor difference that changes the function completely.  This data base is extremely useful in identifying the proteins that cause specific disorders.

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